reactome-db-mcp

An MCP server that gives coding agents direct SQL access to a locally hosted Reactome database — schema discovery, a guarded read-only query(), and ergonomic helpers over the full GKB relational schema, all from the chat.

Built with the official Python MCP SDK (FastMCP) over stdio. It talks straight to MySQL with pure-Python PyMySQL (run via asyncio.to_thread), so there is no build toolchain to install.

reactome-db-mcp vs reactome-mcp

They are complementary — register both:

Tool names are deliberately distinct (get_object vs get_entry, search_by_name vs search, …) so both can be registered without ambiguity.

Prerequisites — the local database

This server needs a running MySQL with the Reactome gk_current dump loaded as reactome_local, reachable by a read-only user. On this machine that is already set up:

• MySQL 9.6 (Homebrew), database reactome_local (~990 MB, 242 MyISAM tables, Reactome release 96).
• Read-only user ro_user@localhost, empty password, SELECT-only.

If mysqld isn't running (it is not registered with brew services, so it won't survive a reboot):

brew services start mysql      # reliable auto-start, or:  /opt/homebrew/opt/mysql/bin/mysqld_safe &

To rebuild the DB from scratch, see ../reactome_local_build (keeps gk_current.sql.gz).

Quickstart

Requires uv (which manages Python ≥ 3.12 for you).

cd reactome-db-mcp
uv sync                     # install runtime deps (mcp, PyMySQL)
uv run reactome-db-mcp      # boots the server on stdio (Ctrl+C to exit)

Then register it with your agent (below) and ask something like:

"Using the reactome-db tools, look up R-HSA-69278, then list its child events in order."

Register with your agent

Standard stdio MCP server launched with uv run reactome-db-mcp. Run from inside the cloned directory.

Claude Code

claude mcp add reactome-db -- uv --directory "$PWD" run reactome-db-mcp

Codex

codex mcp add reactome-db -- uv --directory "$PWD" run reactome-db-mcp

Cursor / any other MCP client — point it at the same stdio command; a ready-to-edit example lives in .mcp.json:

{
  "mcpServers": {
    "reactome-db": {
      "type": "stdio",
      "command": "uv",
      "args": ["run", "--directory", "/absolute/path/to/reactome-db-mcp", "reactome-db-mcp"],
      "env": { "REACTOME_DB_NAME": "reactome_local" }
    }
  }
}

Tools

All tools are async and return JSON-shaped dicts, degrading to {"error": ...} rather than raising on bad input or a down database.

Schema discovery

Guarded raw SQL

Ergonomic helpers (sugar over the common joins)

Design notes

• Read-only by construction. The connection is a SELECT-only user (writes fail at the server), PyMySQL rejects stacked statements by default, and query() additionally checks that the statement is a single read. The string check is for clear errors, not as the security boundary — the grant is.
• Stable ids vs DB_IDs. Helpers accept either R-HSA-69278 or the numeric DB_ID. The 'R-HSA-...' text lives in StableIdentifier, joined via DatabaseObject.stableIdentifier.
• Size-guarded. Every result is row-capped (max_rows, hard ceiling 5000) and long text cells are truncated; truncated flags either.
• Point-in-time data. This is a dump (release reported by schema_overview). For the always-current Reactome, use the sibling reactome-mcp.

Configuration (env vars)

Example prompts

1. Lookup + drill-down — "Look up R-HSA-69278 with the reactome-db tools and list its child events in order."
2. Raw SQL — "Run `SELECT _class, COUNT() FROM DatabaseObject GROUP BY _class ORDER BY 2 DESC LIMIT 10` and summarize."*
3. Reverse navigation — "Which pathways and reactions reference the object named 'CYCB:CDK1'? Use get_referrers."
4. Schema spelunking — "Call schema_overview, then describe the Pathway and Pathway_2_hasEvent tables."

Development

uv sync --extra dev     # pytest, pytest-asyncio
uv run pytest           # safety-layer suite runs fully offline (no DB)

# opt-in live-DB integration tests (needs reactome_local up):
REACTOME_DB_MCP_INTEGRATION=1 uv run pytest

Smoke-test the live server:

uv run reactome-db-mcp                          # console script
uv run python -m reactome_db_mcp                # module entry point
uv run python server.py                         # source-checkout shim
uv run mcp dev src/reactome_db_mcp/server.py    # MCP Inspector dev UI

reactome-db-mcp/
├── src/reactome_db_mcp/
│   ├── server.py   # FastMCP app, lifespan pool, all tools + resource
│   ├── db.py       # PyMySQL pool + read-only safety layer (pure, tested)
│   └── schema.py   # curated schema primer + class-inheritance map
├── server.py       # source-checkout compatibility shim
├── tests/          # offline safety-layer suite + opt-in DB integration tests
├── pyproject.toml  # uv-managed project
├── .mcp.json       # example stdio MCP config
└── PLAN.md         # design & build record (verified 2026-06-22)

Acknowledgements

Powered by Reactome, a free, open-source, open-access, curated and peer-reviewed pathway database. Please cite Reactome when publishing work that uses this data — see <https://reactome.org/cite>.

This project is not affiliated with or endorsed by the Reactome team.

License

MIT © Tien Comlekoglu