Is variant-interpretation-acmg safe to install?

SaferSkills independently audited variant-interpretation-acmg (Agent Skill) and scored it 100/100 (green). The audit ran 55 deterministic rules across Security, Supply Chain, Maintenance, Transparency, and Community; it found 0 high-severity and 0 lower-severity findings. The full rule-by-rule trace and per-finding evidence are below. Free, methodology-open.

CategoryWeightCategory scoreContribution

Securityprompt, exec, net, exfil, eval

35%

100

35.0 pts

Supply chainhash, typosquat, maintainer, lockfile

20%

100

20.0 pts

Maintenancestaleness, pinning, CI

15%

100

15.0 pts

TransparencySKILL.md, perms, README

15%

100

15.0 pts

Communityinstalls, verify, response

15%

100

15.0 pts

Findings & checks · 0 flagged

Securityscore 100 · 0 findings

✓—All security checks passedNo findings in this category for the latest scan.pass

Supply chainscore 100 · 0 findings

✓—All supply chain checks passedNo findings in this category for the latest scan.pass

Maintenancescore 100 · 0 findings

✓—All maintenance checks passedNo findings in this category for the latest scan.pass

Transparencyscore 100 · 0 findings

✓—All transparency checks passedNo findings in this category for the latest scan.pass

Communityscore 100 · 0 findings

✓—All community checks passedNo findings in this category for the latest scan.pass

The primary manifest — the file an agent reads to learn what this artifact does.

skills/variant-interpretation-acmg/SKILL.md · 1 file

skills/variant-interpretation-acmg/SKILL.md1.4 KB · Markdown

name: 'variant-interpretation-acmg'

description: 'Classifies genetic variants according to ACMG (American College of Medical Genetics) guidelines.'

measurable_outcome: Execute skill workflow successfully with valid output within 15 minutes.

allowed-tools:

- read_file

- run_shell_command

Variant Interpretation (ACMG)

The Variant Interpretation Skill automates the classification of genetic variants (Pathogenic, Benign, VUS) using a rules-based engine derived from ACMG guidelines.

When to Use This Skill

When analyzing a VCF file for clinical reporting.
To determine the clinical significance of a specific mutation (e.g., BRCA1 c.123A>G).
To aggregate evidence (population freq, computational predictions) into a final verdict.

Core Capabilities

Rule Scoring: Applies codes like PVS1 (Null variant), PM2 (Rare), PP3 (In silico).
Classification: Combines scores to reach a verdict (Pathogenic, Likely Pathogenic, VUS, etc.).
Explanation: Provides the logic/evidence used for the classification.

Workflow

Input: Variant details (Gene, HGVS, Consequence) or Evidence codes directly.
Process: Sums weights of applied ACMG criteria.
Output: Final classification and score breakdown.

Example Usage

User: "Classify a variant with evidence PVS1 and PM2."

Agent Action:

python3 Skills/Genomics/Variant_Interpretation/acmg_classifier.py \
    --evidence "PVS1,PM2"

variant-interpretation-acmg— agent skill

Is variant-interpretation-acmg safe to install?

Variant Interpretation (ACMG)

When to Use This Skill

Core Capabilities

Workflow

Example Usage

Audit the pieces. Scan the whole. Decide.