Mcp Guidetopharmacology — independently scanned and version-tracked by SaferSkills.
SaferSkills independently audited Mcp Guidetopharmacology (Agent Skill) and scored it 100/100 (green). The audit ran 55 deterministic rules across Security, Supply Chain, Maintenance, Transparency, and Community; it found 0 high-severity and 0 lower-severity findings. The full rule-by-rule trace and per-finding evidence are below. Free, methodology-open.
Findings & checks · 0 flagged
Every scanned point with the score it earned and what moved between them.
First recorded scan — no prior version to compare against.
The primary manifest — the file an agent reads to learn what this artifact does.
IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb) MCP — BYO key. Expert-curated pharmacology database of drug targets, ligands, and their interactions.
Part of Pipeworx — an MCP gateway connecting AI agents to 1856+ live data sources. This is an independent, unofficial integration — not affiliated with, endorsed by, or published by the upstream provider.
| Tool | Description |
|---|---|
search_ligands | Search the Guide to PHARMACOLOGY (IUPHAR/BPS) — an expert-curated pharmacology database — for drug ligands by name. Returns matching ligands with their GtoPdb ligand id, type (e.g. Synthetic organic, Peptide, Antibody, Metabolite), and approval status. Use the returned ligand id with ligand_interactions to find which protein targets it acts on. Requires a GtoPdb API key — register free at guidetopharmacology.org/login.jsp and pass your own via _apiKey. Complements ChEMBL/DrugBank. |
search_targets | Search the Guide to PHARMACOLOGY (IUPHAR/BPS) — an expert-curated pharmacology database — for protein targets by name. Returns matching targets with their GtoPdb target id, abbreviation, and type (e.g. GPCR, CatalyticReceptor, Enzyme, Transporter). Use the returned target id with target_interactions to find ligands that bind it. Requires a GtoPdb API key — register free at guidetopharmacology.org/login.jsp and pass your own via _apiKey. Complements ChEMBL/DrugBank. |
target_interactions | List the quantitative ligand interactions for a protein target in the Guide to PHARMACOLOGY (IUPHAR/BPS). Given a GtoPdb target id (from search_targets), returns the ligands acting on it with interaction type (Agonist/Antagonist/Inhibitor/etc.), action, and binding affinity (e.g. pKi/pIC50). Requires a GtoPdb API key — register free at guidetopharmacology.org/login.jsp and pass your own via _apiKey. |
ligand_interactions | What proteins a drug acts on — the curated target interactions for a ligand in the Guide to PHARMACOLOGY (IUPHAR/BPS), each with the target PROTEIN NAME, interaction type (Agonist/Antagonist/Inhibitor), action and binding affinity (pKi/pIC50). Pass the drug by name ("imatinib") and it is resolved for you; a GtoPdb ligand id also works. The response always names the ligand it actually read, so an id that turns out to be a different compound is visible rather than silent. Requires a GtoPdb API key — register free at guidetopharmacology.org/login.jsp and pass your own via _apiKey. |
Add to your MCP client (Claude Desktop, Cursor, Windsurf, etc.):
{
"mcpServers": {
"guidetopharmacology": {
"url": "https://gateway.pipeworx.io/guidetopharmacology/mcp"
}
}
}tools/list at https://gateway.pipeworx.io/guidetopharmacology/mcp returns the tools in the table above plus the shared Pipeworx meta-tools — ask_pipeworx, discover_tools, search_within, remember/recall and the rest of the gateway-wide set. So the tool count you see is larger than this table: a single-pack endpoint currently lists roughly 30 shared tools alongside the pack's own. The connection's initialize response states its exact scope, and is the authoritative answer for a given day.
This is deliberate, not multiplexing by accident. The meta-tools are what let a scoped connection answer a question this pack does not cover — via ask_pipeworx, which routes across the whole catalog — without you adding a second MCP server. There is currently no way to mount a pack endpoint without them; if the extra schemas cost you more context than the routing is worth, connect to the full gateway once rather than to several pack endpoints.
Or connect to the full Pipeworx gateway to get every pack's tools listed directly, instead of just this one's:
{
"mcpServers": {
"pipeworx": {
"url": "https://gateway.pipeworx.io/mcp"
}
}
}Both URLs reach the same gateway and the same 1856+ data sources. The only difference is which pack's tools are listed directly; ask_pipeworx reaches all of them from either one.
This pack takes your own API key (_apiKey) — we don't front one for it, so there's no curl here that would run without it. Inspect any tool: GET https://gateway.pipeworx.io/v1/tools/search_ligands. Find one: POST https://gateway.pipeworx.io/v1/tools/search_packs with {"query":"..."}.
@pipeworx/mcp-guidetopharmacology is a local stdio bridge to the Pipeworx gateway: your MCP client starts it with npx, and it forwards every call to the same https://gateway.pipeworx.io/guidetopharmacology/mcp endpoint shown above. It needs network access; there is no offline mode.
{
"mcpServers": {
"guidetopharmacology": {
"command": "npx",
"args": ["-y", "@pipeworx/mcp-guidetopharmacology"]
}
}
}Without a key it calls anonymously, capped at 50 calls a day. A free account raises that to 200 a day: get a key at https://pipeworx.io/signup and add "env": { "PIPEWORX_API_KEY": "<your key>" } to the server entry. The key is sent as a Bearer token, the same way a hosted connection sends it, so calls are metered and billed exactly as they are there.
It lists only this pack's tools by default. Set PIPEWORX_META_TOOLS=1 to also list ask_pipeworx and the other gateway-wide tools.
Behind an HTTPS proxy: Node's built-in fetch does not read HTTPS_PROXY by default. Newer Node releases honour it when NODE_USE_ENV_PROXY=1 is set; check your Node version's documentation.
Instead of calling tools directly, you can ask questions in plain English — this works on the pack endpoint above as well as on the full gateway:
ask_pipeworx({ question: "your question about Guidetopharmacology data" })The gateway picks the right tool and fills the arguments automatically.
MIT
~30 seconds. Free. No account. Every finding cites a rule and a line of evidence.